| 摘要 |
PURPOSE: A novel manufacturing method of benzoporphyrin derivative is provided to drastically reduce manufacturing steps in order to economically manufacture benzoporphyrin derivative. CONSTITUTION: A novel manufacturing method of benzoporphyrin derivative comprises the following steps: manufacturing a compound which is represented by chemical formula 3 by reacting diene with diels-alder under the presence of an organic solvent after reacting a compound which is represented by chemical formula 2 with formic acid; manufacturing a compound represented by chemical formula 4 by reacting the compound of chemical formula 3 with ammonium hydroxide and organic solvent; manufacturing a tetrabenzoporphyrin precursor represented by chemical formula 5 by reacting the compound of the chemical formula 4 under the presence of acid and organic solvent; and manufacturing the tetrabenzoporphyrin of the chemical formula 1 by processing the tetrabenzoporphyrin precursor at high temperature. The organic solvent of the first step is ethyl acetate, methylene chloride, acetone, hexane, diethylether or diisopropyl ether. |
