发明名称 MGMT-BASED METHOD FOR OBTAINING HIGH YIELD OF RECOMBINANT PROTEIN EXPRESSION
摘要 The present invention relates to a novel enhancer of protein production in host cells. It discloses a vector for expressing recombinant proteins in these cells, comprising a nucleotide sequence encoding a) a secretion peptidic signal, b) a 6-methylguanine-DNA-methyltransferase enzyme (MGMT, EC 2.1.1.63), a mutant or a catalytic domain thereof, and c) a recombinant protein. Said MGMT enzyme is preferably the so-called SNAP protein.
申请公布号 EP2649178(A1) 申请公布日期 2013.10.16
申请号 EP20110791602 申请日期 2011.12.09
申请人 INSTITUT PASTEUR 发明人 DESPRES, PHILIPPE;PAULOUS, SYLVIE;CRUBLET, ELODIE
分类号 C12N9/10;C12N15/62 主分类号 C12N9/10
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