| 摘要 |
<p>The problem to be solved of the present application is to provide a method for producing a novel pyrimidine derivative from an inexpensive compound which is industry-available with ease, and a method for producing an important intermediate of an HMG-CoA reductase inhibitor. The problem can be solved by, for example, reacting the compound (1) with the compound represented by (OR 1 ) 3P to obtain the phosphonate ester (3) and reacting the phosphonate ester (3) with the compound (4) in the presence of a base to obtain an HMG-CoA reductase inhibitor intermediate (5).</p> |
