发明名称 |
SYNTHETIC MINI/MICRO-DYSTROPHIN GENES TO RESTORE NNOS TO THE SARCOLEMMA |
摘要 |
<p>The present invention provides novel dystrophin mini/micro-genes that retain the essential biological functions of a full-length dystrophin gene. More particularly, the present invention provides to a series of synthetic mini/micro-dystrophin genes capable of restoring neuronal nitric oxide synthase (nNOS) to the sarcolemma. A method as well as a pharmaceutical composition for treatment of Duchenne Muscular Dystrophy (DMD), Becker Muscular Dystrophy (BMD), and X-linked Dilated Cardiomyopathy (XLDC) are also provided.</p> |
申请公布号 |
EP2125006(B1) |
申请公布日期 |
2013.10.16 |
申请号 |
EP20080724643 |
申请日期 |
2008.01.18 |
申请人 |
UNIVERSITY OF MISSOURI-COLUMBIA |
发明人 |
DONGSHENG, DUAN;LAI, YI;YUE, YONGPING |
分类号 |
A61K39/00;A01N43/04;C07H21/04;C07K1/00;C12N15/00;C12N15/63;C12P21/04 |
主分类号 |
A61K39/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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