Bio-corrodable implant with a coating containing a polymer matrix carrying an active agent

摘要

A stent comprises a base body comprising a biocorrodible metallic material which decomposes in an aqueous environment to form an alkaline product. The base body has a coating, and a cavity filling comprising a polymer matrix and a drug(s) embedded in the polymer matrix. The polymer of the polymer matrix and the drug(s) are coordinated so that the drug elution rate from the polymer matrix is increased at an elevated pH. The stent has an additional outer coating containing a degradable polymer.