发明名称 |
SITAGLIPTIN INTERMEDIATES, PREPARATION METHODS AND USES THEREOF |
摘要 |
The present invention relates to Sitagliptin intermediate and preparation method and use thereof. The method comprises reacting compound of formula (II) and trifluorobromobenzene with a Grignard reagent by a Grignard reaction to obtain a compound of formula (I). Compound of formula (I) is a new intermediate compound for the synthesis of Sitagliptin. Compound of formula (I) can be easily used for preparing another important intermediate compound of formula (V) for the synthesis of Sitagliptin. The structures of the compounds mentioned above are as the following: |
申请公布号 |
EP2481722(A4) |
申请公布日期 |
2013.10.16 |
申请号 |
EP20100818419 |
申请日期 |
2010.09.25 |
申请人 |
ZHEJIANG JIUZHOU PHARMACEUTICAL CO., LTD. |
发明人 |
ZHU, GUOLIANG;ZHANG, JIAN;YANG, LIJUN;YAO, QINGDAN;YING, JIE |
分类号 |
C07C229/34;C07C213/00;C07C215/28;C07C227/14;C07D487/04 |
主分类号 |
C07C229/34 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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