发明名称 |
USE OF FERTILE TRANSGENIC ANIMALS FOR PRODUCING ANTIBODIES BEARING HUMAN VARIABLE REGIONS |
摘要 |
The present invention relates inter alia to fertile non-human vertebrates such as mice and rats useful for producing antibodies bearing human variable regions, in which endogenous antibody chain expression has been inactivated. This inactivation leads to loss of ADAM6 genes located within the rodent heavy chain locus, said genes being important for fertility. Introduction of functional copies of said ADAM6 genes is shown to allow production of fertile mice. |
申请公布号 |
EP2649184(A1) |
申请公布日期 |
2013.10.16 |
申请号 |
EP20120795606 |
申请日期 |
2012.11.30 |
申请人 |
KYMAB LIMITED |
发明人 |
FRIEDRICH, GLENN A;LEE, E-CHIANG |
分类号 |
C12N15/85;A01K67/027;C07K16/00;C12N9/64 |
主分类号 |
C12N15/85 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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