发明名称 |
Mineralized three-dimensional bone constructs |
摘要 |
The present disclosure provides ex vivo-derived mineralized three-dimensional bone constructs. The bone constructs are obtained by culturing osteoblasts and osteoclast precursors under randomized gravity vector conditions. Preferably, the randomized gravity vector conditions are obtained using a low shear stress rotating bioreactor, such as a High Aspect Ratio Vessel (HARV) culture system. The bone constructs of the disclosure have utility in physiological studies of bone formation and bone function, in drug discovery, and in orthopedics.
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申请公布号 |
US8557576(B2) |
申请公布日期 |
2013.10.15 |
申请号 |
US20100781482 |
申请日期 |
2010.05.17 |
申请人 |
CLARKE MARK S. F.;SUNDARESAN ALAMELU;PELLIS NEAL R.;THE UNITED STATES OF AMERICA AS REPRESENTED BY THE NATIONAL AERONAUTICS AND SPACE ADMINISTRATION;UNIVERSITY OF HOUSTON;UNIVERSITIES SPACE RESEARCH ASSOCIATION |
发明人 |
CLARKE MARK S. F.;SUNDARESAN ALAMELU;PELLIS NEAL R. |
分类号 |
C12N5/07;A61F2/28;C12N5/077 |
主分类号 |
C12N5/07 |
代理机构 |
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