GLIMEPIRIDE- AND INSULIN-INDUCED GLYCOSYLPHOSPHATIDYLINOSITOL-SPECIFIC PHOSPHOLIPASE C REGULATION

摘要

The present invention refers to a method for identification of a chemical compound which modulates the activity of mammalian GPI-PLC wherein a] a mammalian cell is incubated with glimepiride; b] hcDlGs of the cells of a] are prepared; c] the hcDlGs from b] are incubated with a chemical compound; d] the activity of the GPI-PLC from the hcDlGs of c] is determined.