发明名称 Method for producing a water-insoluble amorphous or partially amorphous controlled release matrix
摘要 The invention relates to a method for producing pharmaceutical forms or preliminary stages thereof by means of extrusion. The pharmaceutical form has a matrix which the active agent is contained essentially, and whose essential characteristics are determined by the extrusion process and which comprises a polysaccharide and/or derivative thereof and/or a complex thereof and/or any mixture of the aforementioned substances with other substances and/or saccharides and/or derivatives thereof as an essential constituent, and at least one pharmaceutically active substance. The invention also relates to a pharmaceutical form which has a matrix in which the active agent is contained essentially, and whose essential characteristics are determined by the extrusion process, and which comprises a polysaccharide and/or derivative thereof and/or a complex thereof and/or any mixture of the aforementioned substances with other substances and/or saccharides and/or derivatives thereof as an essential constituent, and at least one pharmaceutically active substance. Finally, the invention also relates to the use of said pharmaceutical form for producing granulates for tabletting and filling capsules, for further processing using injection molding techniques and as an auxiliary material for direct tabletting and/or for producing monobloc pharmaceutical forms.
申请公布号 US8557286(B1) 申请公布日期 2013.10.15
申请号 US20000980727 申请日期 2000.04.20
申请人 REIN HUBERT;STEFFENS KLAUS-JURGEN;EUROCELTIQUE, S.A. 发明人 REIN HUBERT;STEFFENS KLAUS-JURGEN
分类号 A61K9/14;A61K9/16;A61K9/20;A61K9/22;A61K9/26;A61K9/62;A61K31/522;A61K47/26;A61K47/36;A61P25/26 主分类号 A61K9/14
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