发明名称 |
PYRAZOLOPYRIMIDINE DERIVATIVES, INHIBITING COMPOSITION OF PRODUCING NITRIC OXIDE AND PHARMACEUTICAL COMPOSITION FOR PREVENTION AND TREATMENT OF DISEASES COMPRISING THE SAME |
摘要 |
PURPOSE: A composition containing a pyrazolopyrimidine derivative compound for suppressing NO generation and a pharmaceutical composition containing the pyrazolopyrimidine derivative compound for preventing and treating neurological disorders are provided to suppress NO generation in vivo and to treat neurological disorders caused by functional disturbance and apoptosis of neural cells. CONSTITUTION: A pyrazolopyrimidine derivative compound of chemical formulas I-VII or a pharmaceutically acceptable salt thereof is provided. A pharmaceutical composition for suppressing NO generation contains a pharmaceutically acceptable carrier or diluent and the compounds as active ingredients. A composition for treating neurological disorders contains the pharmaceutically acceptable carrier or diluent and the compounds as active ingredients. The neurological diseases are selected among Parkinson's disease, Alzheimer's disease, Huntington's disease, amylotrophic lateral sclerosis, epilepsia, depression, pain, anxiety, and neurodegenerative diseases. |
申请公布号 |
KR20130112248(A) |
申请公布日期 |
2013.10.14 |
申请号 |
KR20120034483 |
申请日期 |
2012.04.03 |
申请人 |
KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY;UNIVERSITY OF ULSAN FOUNDATION FOR INDUSTRY COOPERATION |
发明人 |
CHEONG, CHAN SEONG;KIM, DONG JIN;PARK, KI DUK;KIM, YUN KYUNG;PYO, JUNG IN;KIM, HYUN TAE;HWANG, ON YOU;ASHRAFUZZAMAN MD.;SONG, CHI MAN;KIM, YOUNG SOO |
分类号 |
C07D487/04;A61K31/519;A61P25/00 |
主分类号 |
C07D487/04 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|