发明名称 |
New isolated antisense-oligonucleotide comprising sequence that is hybridized to messenger RNA-splicing-sequence of mutation-bearing exons of pre-messenger RNA of titin-gene and induces skipping of exons, used to treat heart disease |
摘要 |
<p>Isolated antisense-oligonucleotide (AO) comprising a sequence that is specifically hybridizable to a messenger RNA (mRNA)-splicing-sequence of mutation-bearing exons of pre-mRNA of titin-gene and is able to induce a skipping of the exons is new. ACTIVITY : Cardiant; Cardiovascular-Gen. MECHANISM OF ACTION : Angiotensin-converting enzyme inhibitor; Beta-blocker.</p> |
申请公布号 |
DE102012103041(A1) |
申请公布日期 |
2013.10.10 |
申请号 |
DE201210103041 |
申请日期 |
2012.04.10 |
申请人 |
EBERHARD-KARLS-UNIVERSITAET TUEBINGEN UNIVERSITAETSKLINIKUM |
发明人 |
GAWAZ, MEINRAD;GRAMLICH, MICHAEL |
分类号 |
A61K31/713 |
主分类号 |
A61K31/713 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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