发明名称 |
EWING'S SARCOMA BIFUNCTIONAL SHRNA DESIGN |
摘要 |
<p>The present invention includes compositions and methods of making and using an imaging label comprising an expression vector comprising a promoter; and a nucleic acid insert operably linked to the promoter, wherein the insert encodes one or more short hairpin RNAs (shRNA) capable of inhibiting an expression of a target gene sequence that is a EWS-FLI1 fusion gene, a EWSRl-ERG fusion gene, or both in Ewing's sarcoma via RNA interference; wherein the one or more shRNA comprise a bifunctional RNA molecule that activates a cleavage-dependent and a cleavage-independent RNA-induced silencing complex for reducing the expression level of the target gene.</p> |
申请公布号 |
WO2013151981(A1) |
申请公布日期 |
2013.10.10 |
申请号 |
WO2013US34921 |
申请日期 |
2013.04.02 |
申请人 |
GRADALIS, INC. |
发明人 |
NEMUNAITIS, JOHN, J.;RAO, DONALD;SENZER, NEIL |
分类号 |
C12N15/113;A61K9/127;A61K48/00;A61P35/00;B82Y5/00;C12N15/09;C12N15/63;C12N15/85 |
主分类号 |
C12N15/113 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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