| 摘要 |
PROBLEM TO BE SOLVED: To provide formulations and methods for improving stability upon exposure to aqueous media of polypeptides present in non-aqueous suspension vehicles.SOLUTION: In particular aspects, formulations are provided that comprise a complex of a metal ion and a polypeptide suspended in a non-aqueous, biocompatible suspension vehicle. The non-aqueous, biocompatible suspension vehicle comprises: a polymer selected from the group comprising polylactic acid (PLA), polylacticpolyglycolic acid, polyvinylpyrrolidone, polyoxyethylenepolyoxypropylene block copolymer, and polyvinyl acetate; and a combination of benzyl alcohol and benzyl benzoate, as a solvent. Aggregation of individual polypeptide molecules is reduced when aqueous media is introduced to such formulations, serving to stabilize the polypeptide. |
