发明名称 |
NATURAL-KILLER/T-CELL LYMPHOMA (NKTCL) SUSCEPTIBILITY PREDICTION, DIAGNOSIS AND THERAPY |
摘要 |
Natural-KilleifT-Cell Lymphoma (NKTCL) susceptibility prediction, diagnosis and therapy. The invention relates to a method for predicting Natural Killer T-cell Lymphoma (NKTCL) susceptibility and/or diagnosing NKTCL in a subject comprising testing for JAK mutations. The invention also relates to a method of screening for candidate agents capable of treating NKTCL using a cell line comprising at least one JAK mutation. The invention includes an NKTCL animal model comprising at least one JAK mutation. The invention also includes JAK inhibitors for treating NKTCL. |
申请公布号 |
WO2013077814(A3) |
申请公布日期 |
2013.10.10 |
申请号 |
WO2012SG00444 |
申请日期 |
2012.11.26 |
申请人 |
SINGAPORE HEALTH SERVICES PTE LTD |
发明人 |
TEH, BIN TEAN;LIM, SOON THYE |
分类号 |
A61K31/00;C12Q1/68 |
主分类号 |
A61K31/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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