| 摘要 |
FIELD: medicine, pharmaceutics.SUBSTANCE: group of inventions refers to medicine, and concerns a liposomal drug preparation containing a polyvalent ionic preparation as an active substance with one or more dissociating groups at dissociation constant 4.5-9.5, wherein a liposome has a size of about 30-80 mm and a phospholipid bilayer has a phospholipid with a phase transition temperature above the body temperature so that the phase transition temperature of the liposome is above the body; a method of treating a tumour in a patient involving administering the above liposomal drug preparation.EFFECT: group of inventions provides the higher therapeutic efficacy index of the liposomal preparation, especially more effective control of liposomal drug preparation recovery after targeted on the involved area, reduced loss of the drug preparation during the blood circulation of the liposomal drug preparation and more effective drug release into the target tissues.17 cl, 21 ex, 3 dwg, 9 tbl |
