摘要 |
PROBLEM TO BE SOLVED: To provide carbocyclic and heterocyclic spiro compounds which inhibit cathepsins and the use thereof as medicaments.SOLUTION: Carbocyclic and heterocyclic spiro compounds comprise N-[(S)-1-(1-cyanocyclopropylcarbamoyl)-3-methylbutyl]-1,4-dioxaspiro[4.5]decane-8-carboxamide, N-[1-(1-cyanocyclopropylcarbamoyl)cyclohexyl]-8-azaspiro[4.5]decane-8-carboxamide, N-[(S)-1-(1-cyanocyclopropylcarbamoyl)-cyclohexylmethyl]-8-azaspiro[4.5]decane-8-carboxamide, and N-[(S)-1-(1-cyanocyclopropylcarbamoyl)-3-methylbutyl]spiro[2.3]hexane-1-carboxamide. |