发明名称 |
CHIMERIC RECEPTORS WITH 4-1BB STIMULATORY SIGNALING DOMAIN |
摘要 |
The present invention relates to a chimeric receptor capable of signaling both a primary and a co-stimulatory pathway, thus allowing activation of the co-stimulatory pathway without binding to the natural ligand. The cytoplasmic domain of the receptor contains a portion of the 4-1BB signaling domain. Embodiments of the invention relate to polynucleotides that encode the receptor, vectors and host cells encoding a chimeric receptor, particularly including T cells and natural killer (NK) cells and methods of use.
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申请公布号 |
US2013266551(A1) |
申请公布日期 |
2013.10.10 |
申请号 |
US201313826258 |
申请日期 |
2013.03.14 |
申请人 |
ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC. |
发明人 |
CAMPANA DARIO;IMAI CHIHAYA |
分类号 |
C07K16/28 |
主分类号 |
C07K16/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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