Inhibitors of 17beta-HSD1, 17beta-HSD3 and 17beta-HSD10

摘要

The present application discloses 17βhydroxy steroid dehydrogenase (17βHSD) type 1, 3, 10 inhibitors and use thereof (alone and in combination) in the treatment of cancer and other afflictions. 17βHSDl inhibitors include estradiol derivatives with a nieta-carbamoylbenzyl substituent at C 16. 17βHSD3/HSD10 inhibitors include androsterone derivatives substituted at the C3 position with a sulfonamide piperazine. Also disclosed are compounds that are inhibitors of both 17βHSDl and 17βHSD3 that have a spiro-morpholine substituent at C20.