发明名称 |
MODIFIED SINGLE-STRAND POLYNUCLEOTIDE |
摘要 |
<p>It is intended to provide a polynucleotide that is resistant to RNase and has an RNA interference effect, etc. The present invention provides a single-stranded polynucleotide that is derived from a double-stranded polynucleotide comprising a sense strand polynucleotide corresponding to a target gene, and an antisense strand polynucleotide having a nucleotide sequence complementary to the sense strand polynucleotide, and has a structure in which the 5'-end of the antisense strand and the 3'-end of the sense strand are linked via a phenyl group-containing linker to form a phosphodiester structure at each of these ends.</p> |
申请公布号 |
EP2647713(A1) |
申请公布日期 |
2013.10.09 |
申请号 |
EP20110845160 |
申请日期 |
2011.12.01 |
申请人 |
DAIICHI SANKYO COMPANY, LIMITED |
发明人 |
KOIZUMI, MAKOTO;HIROTA, YASUHIDE;NAKAYAMA, MAKIKO;IKEDA, MIKA |
分类号 |
C12N15/11;A61K31/7088;A61K48/00;C07C37/00;C12N15/113 |
主分类号 |
C12N15/11 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|