A peristaltic pump assembly and system that facilitates reliable and efficient engagement and removal of a flexible tube. A stator is pivotally retained on a structure and cooperatively operated by a lever arm and cam to engage and disengage the stator from the tube and a corresponding rotor. The stator pivots at a point distal from a point of rotation of the rotor and the lever arm moves about a fixed rotation axis to engage and disengage the stator with the tube relative to the rotor.