| 摘要 |
#CMT# #/CMT# Generator for gallium-68 daughter nuclide, comprises germanium-68 parent nuclide, which is specifically immobilized on a carrier by trihydroxyphenyl groups or dihydroxyphenyl groups. The parent nuclide immobilized on the carrier is continuously decayed with a half-life of 270.82 days by electron capture, to obtain gallium-68 daughter nuclide. The trihydroxyphenyl groups or the dihydroxyphenyl groups are covalently bonded to the carrier material by a linker comprising esters with 2-20C, alkylene with 2-20C, phenyl thiourea, amines with 2-20C, melamine or trihydroxyphenyl alkoxysilane. #CMT# : #/CMT# Generator for gallium-68 daughter nuclide, comprises germanium-68 parent nuclide, which is specifically immobilized on a carrier by trihydroxyphenyl groups or dihydroxyphenyl groups. The parent nuclide immobilized on the carrier is continuously decayed with a half-life of 270.82 days by electron capture, to obtain gallium-68 daughter nuclide. The trihydroxyphenyl groups or the dihydroxyphenyl groups are covalently bonded to the carrier material by a linker comprising esters with 2-20C, alkylene with 2-20C, phenyl thiourea, amines with 2-20C, melamine or trihydroxyphenyl alkoxysilane, preferably 1,2,3-trihydroxyphenyl triethoxysilane, 1,2,3-trihydroxyphenyl diethoxysilane, 1,2,3-trihydroxyphenyl ethoxysilane, 1,2,3-trihydroxyphenyl tripropoxysilane, 1,2,3-trihydroxyphenyl chlorosilane, epichlorohydrin, isothiocyanates or thiols. #CMT#USE : #/CMT# The gallium-68 daughter nuclide is useful in radiopharmaceutical applications (claimed). #CMT#ADVANTAGE : #/CMT# The generated gallium-68: exhibits such purity that it is directly usable in radiopharmaceutical applications, where the content of impurities, preferably metallic impurities is 10-100 ppb, preferably less than 1 ppb; and is stable. The gallium-68 generator can be used repeatedly for a long period. #CMT#INORGANIC CHEMISTRY : #/CMT# Preferred Components: The carrier material comprises inert inorganic oxide materials, preferably silica gel (preferred), silicon dioxide, titanium dioxide, tin dioxide, aluminum oxide, zinc oxide, zirconium dioxide or hafnium oxide, inert organic polymers or copolymers, preferably styrene-divinylbenzene, polystyrene, styrene-acrylonitrile, styrene-acrylonitrile-methyl methacrylate, acrylonitrile-methyl methacrylate, polyacrylonitrile, polyacrylates, acrylic or methacrylic esters, acrylonitrile unsaturated dicarboxylic acid-styrene or vinylidene chloride-acrylonitrile. The silica gel exhibits an average grain size of 10-150 mu m and an average pore size of 6-50 nm. The parent nuclide germanium-68 is used in the form of a compound with oxidation number (IV). An aqueous solution of germanium-68(IV) salt, preferably germanium-68 aqua ions are used for immobilizing germanium-68 at trihydroxyphenyl groups. #CMT#ORGANIC CHEMISTRY : #/CMT# Preferred Components: The trihydroxyphenyl groups comprise 1,2,3-trihydroxybenzene. The linker comprises 1,2,3-trihydroxyphenyltriethoxysilane. The trihydroxyphenyl group of the carrier material loaded with germanium-68 is treated with 0.05-0.5 M hydrochloric acid for specific elution of gallium-68 ion formed by radioactive decay of the parent nuclide. #CMT#EXAMPLE : #/CMT# No suitable example given. |
