COMPOSITION FOR SPECIFICALLY INHIBITING SHP-2 ACTIVITY AND METHOD THE SAME

摘要

PURPOSE: A composition which specifically suppresses the activation of Src homology 2-containing protein tyrosine phosphatase (SHP-2) is provided to study SHP-2-related diseases such as LEOPARD syndrome type1, Noonan syndrome, or pigmented villondular synovitis and an SHP-2 mechanism. CONSTITUTION: A compound of chemical formula 1 or a pharmaceutically acceptable salt thereof is provided. A pharmaceutical composition for treating breast cancer, lung cancer, colon cancer, melanoma, neuroblastoma, acute myeloid leukemia, LEOPARD syndrome type1, Noonan syndrome, and pigmented villondular synovitis contains the compound of chemical formula 1 as an active ingredient. The pharmaceutical composition specifically suppresses SHP-2.