GRANULATES CONTAINING UBIDECARENON AND LIPOSOLUBLE VITAMINS FOR VITAMNINE COMPLEX

摘要

PURPOSE: A granule composition with improved solubility and flowability for vitamin complex is provided to enhance ubidecarenon solubility, thereby improving bioavailability and manufacturing a tablet with fat soluble vitamin. CONSTITUTION: A granule composition with improved solubility and flowability for vitamin complex contains 5-10 parts by weight of ubidecarenon, 5-50 parts by weight of poloxamer 407, 0.1-10 parts by weight of fat soluble vitamin selected among vitamin A, D, and E, and 10-200 parts by weight of an adsorption excipient. The granule composition further contains 10-50 parts by weight of omega-3. A method for manufacturing the granule composition comprises the steps of: dissolving fat soluble vitamin, ubidecarenon, and poloxamer 407; adding 10-100 parts by weight of ethanol and uniformly dissolving the mixture; adding the adsorption excipient and adsorbing the mixture; drying the adsorbed mixture; and allowing the adsorbed mixture through a sieve and forming granules.