The present disclosure provides crystalline polymorphic and amorphous forms of (R)-3,5-dimethyl-benzoic acid N-(1-tert-butyl-butyl)-N'-(2-ethyl-3-methoxy- benzoyl)-hydrazide (Compound 1) or (S)-3,5-dimethyl-benzoic acid N-(1-tert-butyl- butyl)-N'-(2-ethyl-3-methoxy-benzoyl)-hydrazide (Compound 2). The present disclosure further provides compositions comprising crystalline polymorphic and amorphous forms of Compound 1 or Compound 2 and an excipient, methods of making crystalline polymorphic or amorphous forms of Compound 1 or Compound 2, and methods of using crystalline polymorphic or amorphous forms of Compound 1 or Compound 2 to regulate gene expression in a cell or in a subject.
申请公布号
WO2013036758(A8)
申请公布日期
2013.10.03
申请号
WO2012US54141
申请日期
2012.09.07
申请人
INTREXON CORPORATION;HORMANN, ROBERT, E.;SHULMAN, INNA;RODEL, EVA;HILFIKER, ROLF;DEPAUL, SUSAN, M.
发明人
HORMANN, ROBERT, E.;SHULMAN, INNA;RODEL, EVA;HILFIKER, ROLF;DEPAUL, SUSAN, M.