发明名称 |
PROCESS OF PREPARING SOLIFENACIN OR SALT THEREOF, AND NOVEL INTERMEDIATE USED IN THE PROCESS |
摘要 |
<p>Disclosed herein is a method of preparing solifenacin or a salt thereof, including the steps of: (a) reacting (R)-quinuclidinol with bis(pentafluorophenyl)carbonate in an organic solvent to prepare a solifenacin intermediate,(3R)-1-azabicyclo[2,2,2]oct-3-yl pentafluorophenylcarbonate, and (b) reacting the solifenacin intermediate with (1S)-1-phenyl-1,2,3,4-tetrahydroisoquinoline in an organic solvent to prepare solifenacin. The method is advantageous in that high-purity solifenacin or a salt thereof can be simply and efficiently prepared with high yield using a novel intermediate.</p> |
申请公布号 |
WO2013147458(A1) |
申请公布日期 |
2013.10.03 |
申请号 |
WO2013KR02358 |
申请日期 |
2013.03.21 |
申请人 |
KYUNG DONG PHARM. CO., LTD. |
发明人 |
LEE, BYOUNG SUK;SHIN, SANG HOON;LEE, KI YOUNG |
分类号 |
C07D453/02;A61K31/439;A61P13/00;C07D401/12 |
主分类号 |
C07D453/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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