发明名称 |
FVIIA-STF COMPLEXES EXHIBITING EXOSITE-MEDIATED SUPER ACTIVITY |
摘要 |
Disclosed are disulphide-linked complexes of a soluble Tissue Factor (sTF) variant of SEQ ID NO:3 comprising the mutation G109C and a Factor VIIa variant of SEQ ID NO. 1, comprising the mutation Q64C and a mutation at position M306 that gives rise to a zymogen-like conformation in the Factor VIIa polypeptide. Said complexes may be used for the treatment of a coagulopathy. |
申请公布号 |
WO2013143876(A1) |
申请公布日期 |
2013.10.03 |
申请号 |
WO2013EP55340 |
申请日期 |
2013.03.15 |
申请人 |
NOVO NORDISK A/S |
发明人 |
OESTERGAARD, HENRIK;NIELSEN, ANDERS LAERKE;OLSEN, OLE HVILSTED |
分类号 |
C12N9/64;A61K38/48;C07K14/705;C07K14/745 |
主分类号 |
C12N9/64 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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