发明名称 |
SH2 DOMAIN VARIANTS |
摘要 |
<p>The present invention relates to variant SH2 domains for binding a phosphotyrosine (pTyr)-containing peptide. The variant SH2 domains of the present invention include a parent SH2 domain having at least one amino acid substitution in a pre-defined region of 15 amino acid positions of the parent SR2 domain, wherein said at least one amino acid substitution increases the affinity of the variant SH2 domain for the pTyr-containing peptide relative to the parent SH2 domain. The present application relates also to methods of using the variant SH2 domains in the treatment of protein kinase-associated disorders, or the diagnosis or prognosis of protein kinase-associated disorders, for isolating and measuring the concentration of pTyr-containing molecules, and as reagents in research.</p> |
申请公布号 |
WO2013142965(A1) |
申请公布日期 |
2013.10.03 |
申请号 |
WO2013CA00279 |
申请日期 |
2013.03.27 |
申请人 |
THE UNIVERSITY OF WESTERN ONTARIO;THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO |
发明人 |
LI, SHUN-CHENG;KANEKO, TOMONORI;CAO, XUAN;SIDHU, SACHDEV SINGH;HUANG, HAIMING |
分类号 |
C07K14/47;A61K38/17;C07K1/22;C12N15/12;G01N33/53 |
主分类号 |
C07K14/47 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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