DRUG DELIVERY SYSTEM CONTAINING SOLID SOLUTION OF WEAKLY BASED AGENT

摘要

PROBLEM TO BE SOLVED: To provide an improved delivery of a weakly based therapeutic agent having a drug release profile suitable for a once daily route (for instance, having pKa of less than 14 and requiring high doses to maintain a target plasma level).SOLUTION: Provided is a pharmaceutical composition containing a TPR bead. The TPR bead contains a TPR coating that contains a solid dispersion of at least one kind of active drug ingredient, a water-insoluble polymer, and an enteric polymer in at least one kind of solubility-enhancing polymer. The active drug ingredient contains a weakly based active drug ingredient having a solubility of 100μg/mL or less with pH 6.8.