PREDICTIVE BIOMARKER USEFUL FOR CANCER THERAPY MEDIATED BY A CDK INHIBITOR
摘要
The present invention provides a predictive biomarker whose expression level is useful for identifying patients responsive to a therapeutically effective dose of a CDK inhibitor. In one embodiment of the invention, the predictive biomarker is the ratio of MCL-1 to BCL-xL (MCL-1:BCL-xL ratio) and the CDK inhibitor is SCH 927965 (Dinaciclib).
申请公布号
WO2013148775(A1)
申请公布日期
2013.10.03
申请号
WO2013US34013
申请日期
2013.03.27
申请人
MERCK SHARP & DOHME CORP.;BOOHER, ROBERT NOLAN;HIRSCH, HEATHER, A.;ZAWEL, LEIGH SCOTT;FAWELL, STEPHEN ERIC
发明人
BOOHER, ROBERT NOLAN;HIRSCH, HEATHER, A.;ZAWEL, LEIGH SCOTT;FAWELL, STEPHEN ERIC