发明名称 |
BICYCLIC OXAZOLE AND THIAZOLE COMPOUNDS AND THEIR USE AS ALLOSTERIC MODULATORS OF MGLUR5 RECEPTORS |
摘要 |
In one aspect, the invention relates to novel bicyclic oxazole and thiazole compounds which are positive allosteric modulators of the metabotropic glutamate receptor subtype 5 ("mGluR5"); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions; and methods for the treatment or prevention of disorders associated with glutamate dysfunction and diseases in which the mGluR5 subtype of receptors is involved. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
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申请公布号 |
US2013261107(A1) |
申请公布日期 |
2013.10.03 |
申请号 |
US201113819273 |
申请日期 |
2011.08.31 |
申请人 |
CONN P. JEFFREY;LINDSLEY CRAIG W.;STAUFFER SHAUN R.;JONES CARRIE K.;BARTOLOME-NEBREDA JOSE MANUEL;CONDE-CEIDE SUSANA;MACDONALD JAMES GREGOR;ALCAZAR VACA MANUEL JESUS;VANDERBILT UNIVERSITY |
发明人 |
CONN P. JEFFREY;LINDSLEY CRAIG W.;STAUFFER SHAUN R.;JONES CARRIE K.;BARTOLOME-NEBREDA JOSE MANUEL;CONDE-CEIDE SUSANA;MACDONALD JAMES GREGOR;ALCAZAR VACA MANUEL JESUS |
分类号 |
C07D513/04;C07D498/04 |
主分类号 |
C07D513/04 |
代理机构 |
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地址 |
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