发明名称 |
DNA METHYLATION ANALYSIS FOR THE DIAGNOSIS, PROGNOSIS AND TREATMENT OF ADRENAL NEOPLASMS |
摘要 |
<p>Disclosed herein are methods for detecting, diagnosing and/or prognosing a malignant adrenocortical tumor. Also disclosed are methods of treating a malignant adrenocortical tumor, such as ACC. In some examples, the method of diagnosing and/or prognosing includes obtaining a sample comprising genomic DNA from a subject at risk of acquiring or suspected to have an adrenocortical tumor; isolating genomic DNA from the sample; and measuring the level of one or more methylated genomic CpG dinucleotide sequences in one or more of the adrenocortical genomic targets in the sample, wherein an increase in the level of methylation of the one or more genomic CpG dinucleotide sequences in the sample compared to a control indicates a malignant adrenocortical tumor.</p> |
申请公布号 |
WO2013148147(A1) |
申请公布日期 |
2013.10.03 |
申请号 |
WO2013US30347 |
申请日期 |
2013.03.12 |
申请人 |
THE U.S.A., AS REPRESENTED BY THE SECRETARY DEPT.OF HEALTH AND HUMAN SERVICES |
发明人 |
KEBEBEW, ELECTRON;RECHACHE, NESRINE, S.;MELTZER, PAUL, S.;WANG, YONGHONG |
分类号 |
C12Q1/68 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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地址 |
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