PROCESS FOR PREPARING ARYL- AND HETEROARYLACETIC ACID DERIVATIVES.

摘要

The invention relates to a process for preparing aryl- and heteroaryl­acetic acids and derivatives thereof by reaction of aryl or heteroaryl halides with malonic diesters in the presence of a palladium catalyst, one or more bases and optionally a phase transfer catalyst. This process enables the preparation of a multitude of functionalized aryl- and heteroarylacetic acids and derivatives thereof, and more particularly also the preparation of arylacetic acids with sterically demanding substituents.