BIOCATALYSTS FOR PRODUCTION OF D-LACTIC ACID FROM GLYCEROL

摘要

A method for fermenting glycerol to D-lactic acid in high yield, productivity and purity using a specific bacterium, and the specific bacterium are provided. One aspect includes a method for producing D-lactic from glycerol by using a lactic-acid producing bacterium, the lactic acid- producing bacterium having an imparted or overexpressed NADH-dependent D-lactate dehydrogenase (IdhA) gene and an imparted or overexpressed ATP-dependent dihydroxyacetone kinase (dhaK) gene, and, in the lactic acid-producing bacterium, expression of an endogenous malate dehydrogenase (mdh) gene is reduced or inactivated, and a glycerol dehydrogenase (dhaD) gene is not imparted or overexpressed. Also provided is such a specific lactic acid- producing bacterium.