发明名称 |
DUAL FUNCTION MARKERS FOR DIAGNOSTICS AND THERAPEUTICS FOR UPPER GASTROINTESTINAL TRACT PRECANCER |
摘要 |
The invention described herein relates to the detection, diagnosis, and treatment of intestinal metaplasias that develop to esophageal, gastric, and pancreatic adenocarcinoma. The stem cells and differentiated cells of these intestinal metaplasias show high expression of CDH17 as well as other proteins. The invention also includes a clonal population of Barrett's esophagus stem cells as well as the stem cells of the surrounding normal epithelia and methods of using them for the detection, diagnosis, and treatment of Barrett's esophagus. |
申请公布号 |
WO2013148984(A1) |
申请公布日期 |
2013.10.03 |
申请号 |
WO2013US34325 |
申请日期 |
2013.03.28 |
申请人 |
NATIONAL UNIVERSITY OF SINGAPORE;AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH;MULTICLONAL THERAPEUTICS, INC;HARVARD UNIVERSITY |
发明人 |
XIAN, WA;MCKEON, FRANK;VINCENT, MATTHEW;HO, KHEK YU |
分类号 |
C12N5/07;C12Q1/68;G01N33/574 |
主分类号 |
C12N5/07 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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