PROTOPANAXATRIOL GINSENOSIDE PREPARATION METHOD

摘要

Disclosed is a protopanaxatriol ginsenoside preparation method, comprising the following steps: (a) protecting the hydroxyl of the protopanaxatriol, exposing a 20-position hydroxyl and at least one of 3-position, 6-position and 12-position hydroxyls to obtain a protopanaxatriol receptor having a part of the hydroxyls protected; (b) the protopanaxatriol receptor obtained in step (a) having a part of the hydroxyls protected conducts a glycosylation reaction with a fully-protected glycosyl donor so as to obtain the protopanaxatriol ginsenoside connected with a fully-protected glycosyl and having the hydroxyls protected; (c) de-protecting the protopanaxatriol ginsenoside obtained in step (b) connected with a fully-protected glycosyl and having the hydroxyls protected, thus obtaining the protopanaxatriol ginsenoside. The chemical synthesis method of the present invention is novel, reliable and efficient, and has high yield and stereoselectivity.