发明名称 CLASS I MHC PHOSPHOPEPTIDES FOR CANCER IMMUNOTHERAPY AND DIAGNOSIS
摘要 A set of phosphorylated peptides are presented by HLA A*0101, A*0201, A*0301, B*4402, B*2705, B*1402, and B*0702 on the surface of melanoma cells. They have the potential to (a) stimulate an immune response to the cancer, (b) to function as immunotherapeutics in adoptive T-cell therapy or as a vaccine, (c) to facilitate antibody recognition of the tumor boundaries in surgical pathology samples, and (d) act as biomarkers for early detection of the disease. Phosphorylated peptides are also presented for other cancers.
申请公布号 US2013259883(A1) 申请公布日期 2013.10.03
申请号 US201113699563 申请日期 2011.05.24
申请人 HUNT DONALD F.;SHABANOWITZ JEFFREY;COTTINE JENNIFER;ENGLISH ANN M.;NORRIS ANDREW;ENGELHARD VICTOR H.;COBBOLD MARK;CUMMINGS KARA L.;ZARLING ANGELA;OBENG REBECCA C.;QIAN JIE;PHOSIMMUNE, INC. 发明人 HUNT DONALD F.;SHABANOWITZ JEFFREY;COTTINE JENNIFER;ENGLISH ANN M.;NORRIS ANDREW;ENGELHARD VICTOR H.;COBBOLD MARK;CUMMINGS KARA L.;ZARLING ANGELA;OBENG REBECCA C.;QIAN JIE
分类号 C07K7/06;A61K39/00;C07K7/08;C07K16/18;G01N33/68 主分类号 C07K7/06
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