发明名称 |
SYSTEM AND METHOD FOR DETERMINING A NUCLEOTIDE SEQUENCE |
摘要 |
Described herein are systems and processes for designing the sequence of one or more interacting nucleic acid strands intended to adopt a target secondary structure at equilibrium. The target secondary structure is decomposed into a binary tree and candidate mutations are evaluated on leaf nodes of the tree. During a process of leaf optimization, defect-weighted mutation sampling is used to select each candidate mutation position with a probability proportional to its contribution to an ensemble defect of the leaf. Subsequences of the tree are then merged, moving up the tree until a final nucleotide sequence of interest is determined that has the target secondary structure at equilibrium.
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申请公布号 |
US2013262071(A1) |
申请公布日期 |
2013.10.03 |
申请号 |
US201313781565 |
申请日期 |
2013.02.28 |
申请人 |
CALIFORNIA INSTITUTE OF TECHNOLOGY |
发明人 |
PIERCE NILES A.;WOLFE BRIAN R.;ZADEH JOSEPH |
分类号 |
G06F19/22 |
主分类号 |
G06F19/22 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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