发明名称 SALICYLIC ACID DERIVATIVES USEFUL AS GLUCOCEREBROSIDASE ACTIVATORS
摘要 Compounds of Formula (I) and the pharmaceutically acceptable salts thereof are disclosed. The variables. R1-R13, m, n, o, and p are disclosed herein. The compounds are useful for treating Gaucher disease and inhibiting the onset of Gaucher disease symptoms in a patient having a GBA gene mutation and for treating Parkinson's disease. Pharmaceutical compositions containing compounds of Formula (I) and methods of treatment comprising administering compounds of Formula (I) are also disclosed.
申请公布号 WO2013148333(A1) 申请公布日期 2013.10.03
申请号 WO2013US32253 申请日期 2013.03.15
申请人 THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES;THE UNIVERSITY OF KANSAS;MARUGAN, JUAN, JOSE;ZHENG, WEI;PATNAIK, SAMARJIT;SOUTHALL, NOEL;SIDRANSKY, ELLEN;GOLDIN, EHUD;WESTBROEK, WENDY;AFLAKI, ELMA;ROGERS, STEVEN, ANDREW;SCHOENEN, FRANK, JOHN 发明人 MARUGAN, JUAN, JOSE;ZHENG, WEI;PATNAIK, SAMARJIT;SOUTHALL, NOEL;SIDRANSKY, ELLEN;GOLDIN, EHUD;WESTBROEK, WENDY;AFLAKI, ELMA;ROGERS, STEVEN, ANDREW;SCHOENEN, FRANK, JOHN
分类号 C07C235/64;A61K31/167;A61P3/00;C07C237/22 主分类号 C07C235/64
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