发明名称 |
COMPOSITE FOR DELIVERING A GENE INTO A CELL AND GENE DELIVERY SYSTEM USING THE SAME |
摘要 |
PURPOSE: A composite for intracellular gene delivery is provided to safely and efficiently deliver a gene to tumor cells and to treat tumor-associated diseases or disorders by binding various genes with anticancer effects. CONSTITUTION: A composite for intracellular gene delivery contains: polyethylene imine which is activated by being conjugated with succinimidyl 4-(N-maleimido-methyl)cyclohexane-1-carboxylate (SMCC); cell penetrating peptides; and tris(2-carboxyethyl)phosphine (TCEP). An anti-tumor composition contains the composite and nucleic acids. The nucleic acids are selected among gDNA, cDNA, pDNA, mRNA, tRNA, rRNA, siRNA, miRNA, and antisense nucleotides. |
申请公布号 |
KR20130107943(A) |
申请公布日期 |
2013.10.02 |
申请号 |
KR20120030145 |
申请日期 |
2012.03.23 |
申请人 |
CHONNAM NATIONAL UNIVERSITY HOSPITAL |
发明人 |
LEE, HWA JEONG;PARK, IN KYU;NAMGUNG, RAN;KIM, WON JONG;KIM, JAE IL |
分类号 |
A61K48/00;A61K47/30;A61K47/48;A61P35/00 |
主分类号 |
A61K48/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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