发明名称 |
Method of increasing the function of an AAV vector |
摘要 |
A method of correcting singletons in a selected AAV sequence in order to increasing the packaging yield, transduction efficiency, and/or gene transfer efficiency of the selected AAV is provided. This method involves altering one or more singletons in the parental AAV capsid to conform the singleton to the amino acid in the corresponding position(s) of the aligned functional AAV capsid sequences. |
申请公布号 |
EP2359865(B1) |
申请公布日期 |
2013.10.02 |
申请号 |
EP20100179260 |
申请日期 |
2006.04.07 |
申请人 |
THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA |
发明人 |
Gao, Guangping;Wilson, James M.;Vandenberghe, Luk |
分类号 |
A61K48/00;A61K35/76;C12N7/00;C12N15/864 |
主分类号 |
A61K48/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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