| 摘要 |
Disclosed is a standardised aqueous biorelevant media for simulating fasted state stomach and fasted state upper small intestinal fluids of mammalian species, composed of surfactants occurring in the gastro intestinal tract of mammals comprising (a) at least 40 mole % to 95 mole % of one bile salt, and (b) the rest mole % being a combination of at least two surfactants, namely a diacyl phospholipid and a fatty acid including monovalent salts of the fatty acid, or a monoacyl phospholipid and a fatty acid including monovalent salts of the fatty acid, or a diacyl phospholipid and a monoacyl phospholipid and a fatty acid including monovalent salts of the fatty acid, or a diacyl phospholipid and a monoacyl phospholipid, which further is defined by a surface tension between 25 mN/m and 50 mN/m. Disclosed is further a homogeneous biorelevant composition for preparing fasted state biorelevant media characterised by a surface tension between 25 mN/m and 50 mN/m comprising the following surfactants: (a) at least 40 mole % to 95 mole % of one bile salt, and (b) the rest mole % being a combination of at least two surfactants, namely a diacyl phospholipid and a fatty acid including monovalent salts of the fatty acid, or a monoacyl phospholipid and a fatty acid including monovalent salts of the fatty acid, or a diacyl phospholipid and a monoacyl phospholipid and a fatty acid including monovalent salts of the fatty acid, or a diacyl phospholipid and a monoacyl phospholipid. |
