发明名称 |
BINDING PARTNERS OF THE PLACENTAL GROWTH FACTOR, ESPECIALLY ANTIBODIES DIRECTED AGAINST THE PLACENTAL GROWTH FACTOR, PRODUCTION AND USE THEREOF |
摘要 |
<p>Immunologically active peptide (I), comprising sequence information of a primary placental growth factor isoform (PIGF), is new. Independent claims are included for: (1) a specific binding partner for PIGF, comprising specifically binding to the receptor binding domain on the secondary PIGF isoform; (2) an antigen binding fragment produced by specific binding partner; (3) a procedure for the production of the specific binding partner comprising immunizing an experimental animal with primary or secondary binding or non-binding (free) PIGF-isoform; fusing the spleen cells of the experimental animal with myeloma cell, where an antibody-producing hybrid cells develops; cloning the hybrid cells and selecting the hybrid cloned cell that produces an antibody selectively, which bind the receptor-binding domain of the secondary PIGF isoform; (4) an immunoassay to detect PIGF in a sample comprising contacting specifically binding partner or antigen binding fragment with the sample; and determining the formation of immune complex under participation of the PIGF qualitatively or quantitatively; (5) a test kit for carrying out immunoassays comprising specific binding partner or the antigen-binding fragment; and (6) a use of antibody and protein of the family receptor-tyrosine kinase, homologous, fragment or degradation in assaying the binding of the PIGF isoform.</p> |
申请公布号 |
EP1888642(B1) |
申请公布日期 |
2013.10.02 |
申请号 |
EP20060742825 |
申请日期 |
2006.05.08 |
申请人 |
SIEMENS HEALTHCARE DIAGNOSTICS PRODUCTS GMBH |
发明人 |
VITZTHUM, FRANK;TEIGELKAMP, STEFAN;ALTHAUS, HARALD |
分类号 |
C07K16/22;C07K7/00 |
主分类号 |
C07K16/22 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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