发明名称 |
ENDOGENOUS RETROVIRUS POLYPEPTIDES LINKED TO ONCOGENIC TRANSFORMATION |
摘要 |
<p>HERV-K human endogenous retroviruses show up-regulated expression in tumors. In particular, splicing events in the env region generate a series of transcripts which utilize the +2 reading frame, relative to the env reading frame. The proteins show activity typical of transcriptional regulators, and they also have oncogenic potential. Two related proteins, PCAP2 and PCAP3, are strongly associated with breast cancer and prostate cancer, respectively. PCAP4 stimulates cell division. These proteins can be used in cancer diagnosis and therapy, and are also drug targets e.g. for adjuvant therapy. The identification of these splice products is remarkable because full sequence information has been available for HERV-K viruses since 1986.</p> |
申请公布号 |
EP1521594(B1) |
申请公布日期 |
2013.10.02 |
申请号 |
EP20020786981 |
申请日期 |
2002.12.09 |
申请人 |
NOVARTIS VACCINES AND DIAGNOSTICS, INC. |
发明人 |
GARCIA, PABLO;HARDY, STEPHEN F.;WILLIAMS, LEWIS T.;ESCOBEDO, JAIME |
分类号 |
C07K14/005;C12N15/09;A61K38/00;A61K39/00;A61K39/39;A61K39/395;A61K48/00;A61P3/10;A61P25/28;A61P35/00;C07K14/15;C07K14/47;C07K16/10;C07K16/18;C12N7/00;C12P21/08;C12Q1/68;C12Q1/70;G01N33/574 |
主分类号 |
C07K14/005 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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