发明名称 |
RABIES VIRUS-BASED RECOMBINANT IMMUNOCONTRACEPTIVE COMPOSITIONS AND METHODS OF USE |
摘要 |
<p>Described herein are recombinant rabies viruses comprising a heterologous nucleic acid sequence encoding an immunocontraceptive protein, such as gonadotropin-releasing hormone (GnRH) or zona pellucida 3 (ZP3). The recombinant rabies viruses disclosed herein are recovered by reverse genetics, replicate efficiently, elicit rabies virus neutralizing antibodies and immunocontraceptive peptide-specific antibodies in vaccinated animals, and protect vaccinated animals against wild-type rabies virus challenge. Further provided is a method of immunizing a non-human animal against rabies virus infection and simultaneously inhibiting fertility of the animal, comprising administering an immunogenic composition comprising one or more of the recombinant rabies viruses described herein.</p> |
申请公布号 |
EP2344193(B1) |
申请公布日期 |
2013.10.02 |
申请号 |
EP20090791746 |
申请日期 |
2009.08.20 |
申请人 |
THE GOVERNMENT OF THE UNITED STATES OF AMERICA ASRERESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH & HUMAN SERVICES |
发明人 |
RUPPRECHT, CHARLES;WU, XIANFU |
分类号 |
A61K39/205;A61K39/00;C07K14/145;C12N15/86 |
主分类号 |
A61K39/205 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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