PREPARATION OF ISOMERICALLY PURE SUBSTITUTED CYCLOHEXANOLS

摘要

Disclosed is a method for preparing isomerically pure substituted cyclohexanols starting from a mixture of cis/trans substituted cyclohexanols, which comprises reacting the cis/trans mixture of a substituted cyclohexanol with a dicarboxylic acid anhydride in the presence of a lipase, to give the trans semi-ester which is separated from the unreacted substituted cyclohexanol cis isomer.