发明名称 |
METHODS AND COMPOSITIONS FOR EXPANDING, IDENTIFYING, CHARACTERIZING AND ENHANCING POTENCY OF MAMMALIAN-DERIVED GLIAL RESTRICTED PROGENITOR CELLS |
摘要 |
Methods for producing a population of human-derived glial restricted progenitor cells (GRPs) with decreased potentially unintended or undesired cellular phenotypes and/or decreased standard deviation in the cells of the population are provided. Also provided are antibody panels and gene expression profiles to characterize GRPs and a method for its use in characterizing GRP cells. In addition methods for use of these GRP cells to generate astrocytes and/or oligodendrocytes, to re-myelinate neurons and to treat glial cell related and other neurodegenerative diseases or disorders or injuries or damage to the nervous system are provided. A method to manufacture neural cells depleted of A2B5 positive cells is also provided. |
申请公布号 |
EP2499238(A4) |
申请公布日期 |
2013.10.02 |
申请号 |
EP20100830580 |
申请日期 |
2010.11.09 |
申请人 |
Q THERAPEUTICS, INC. |
发明人 |
SANDROCK, ROBERT;CAMPANELLI, JAMES, T.;EPPSTEIN, DEBORAH, A. |
分类号 |
C12N5/071;C12N13/00 |
主分类号 |
C12N5/071 |
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代理人 |
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