| 摘要 |
Provided is a novel ubiquitin ligase which has linear polyubiquitination activity and can be efficiently expressed and purified. It was found out that a complex of (a) a protein having a part of HOIP and at least having a UBA region and a RING-IBR-RING region thereof, and (b) One or more kinds of proteins which individually form a complex with the above (a) is a novel ubiquitin ligase which has linear polyubiquitination activity and can be efficiently expressed and purified.
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