发明名称 |
LATENT HUMAN TUBERCULOSIS MODEL, DIAGNOSTIC ANTIGENS, AND METHODS OF USE |
摘要 |
Provided herein is an in vitro granuloma model and methods of its use. Methods of detecting and/or diagnosing latent tuberculosis in a subject are also provided, as are latency-specific antigens (and antibodies thereto), such as .alpha.-crystallin, and methods of identifying and using such molecules. Also provided are immunostimulatory compositions, for instance for use in eliciting an immune response in a subject, such as an immune response to a latent tuberculosis infection. Kits for carrying out the provided methods are also described.
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申请公布号 |
CA2689741(C) |
申请公布日期 |
2013.10.01 |
申请号 |
CA20022689741 |
申请日期 |
2002.01.07 |
申请人 |
THE GOVERNMENT OF THE UNITED STATES OF AMERICA ASREPRESENTED BY THE SEC RETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES, CENTERS FOR DISEA |
发明人 |
QUINN, FREDERICK D.;BIRKNESS, KRISTIN A.;DESLAURIERS, MANON;KING, PETER;BEALL, DAVID S. |
分类号 |
C12N5/078;A61K39/04;A61K45/00;A61K48/00;A61P31/06;C12N1/20;C12N5/06;C12N15/09;C12Q1/02;G01N33/15;G01N33/50;G01N33/53;G01N33/569 |
主分类号 |
C12N5/078 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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