发明名称 |
Substituted [1,2,4]triazolo[4,3-A]pyrazine 11-beta-hydroxysteroid dehydrogenase inhibitors |
摘要 |
Novel compounds are provided which are 1 1-beta-hydroxysteroid dehydrogenase type I inhibitors. 1 1-beta-hydroxysteroid dehydrogenase type I inhibitors are useful in treating, preventing, or slowing the progression of diseases requiring 1 1-beta-hydroxysteroid dehydrogenase type I inhibitor therapy. These novel compounds have the structure: W-L-Z or stereoisomers or prodrugs or pharmaceutically acceptable salts thereof, wherein W, L are defined herein and Z is selected from the following bicyclic heteroaryl groups: (a), (b), (c), (d).
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申请公布号 |
US8546394(B2) |
申请公布日期 |
2013.10.01 |
申请号 |
US20080595524 |
申请日期 |
2008.04.16 |
申请人 |
LI JUN;LI JAMES J.;O'CONNOR STEPHEN P.;WANG HAIXIA;KENNEDY LAWRENCE J.;ROBL JEFFREY A.;HAMANN LAWRENCE G.;BRISTOL-MYERS SQUIBB COMPANY |
发明人 |
LI JUN;LI JAMES J.;O'CONNOR STEPHEN P.;WANG HAIXIA;KENNEDY LAWRENCE J.;ROBL JEFFREY A.;HAMANN LAWRENCE G. |
分类号 |
A61K31/495 |
主分类号 |
A61K31/495 |
代理机构 |
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